Access

Brief Communication

Nature Neuroscience 10, 543–545 (1 May 2007) | doi:10.1038/nn1884

CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock

Jason P DeBruyne , David R Weaver & Steven M Reppert

Heterodimers of CLOCK and BMAL1, bHLH-PAS transcription factors, are believed to be the major transcriptional regulators of the circadian clock mechanism in mammals. However, a recent study shows that CLOCK-deficient mice continue to exhibit robust behavioral and molecular rhythms.