Amyotrophic lateral sclerosis (ALS) is characterized by the selective degeneration of motor neurons. Two independent studies in this issue show that astrocytes expressing a mutation in the enzyme superoxide dismutase can exacerbate motor neuron death, supporting previous suggestions that non-neuronal cells contribute to ALS pathogenesis.
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Astroglia acquires a toxic neuroinflammatory role in response to the cerebrospinal fluid from amyotrophic lateral sclerosis patients
Journal of Neuroinflammation Open Access 30 August 2016
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Julien, JP. ALS: astrocytes move in as deadly neighbors. Nat Neurosci 10, 535–537 (2007). https://doi.org/10.1038/nn0507-535
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DOI: https://doi.org/10.1038/nn0507-535
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