Brief Communication abstract
Nature Neuroscience 10, 543 - 545 (2007)
Published online: 8 April 2007 | doi:10.1038/nn1884
CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock
Jason P DeBruyne1, David R Weaver1 & Steven M Reppert1
Heterodimers of CLOCK and BMAL1, bHLH-PAS transcription factors, are believed to be the major transcriptional regulators of the circadian clock mechanism in mammals. However, a recent study shows that CLOCK-deficient mice continue to exhibit robust behavioral and molecular rhythms. Here we report that the transcription factor NPAS2 (MOP4) is able to functionally substitute for CLOCK in the master brain clock in mice to regulate circadian rhythmicity.
- Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA.
Correspondence to: Steven M Reppert1 e-mail: steven.reppert@umassmed.edu
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