Supplementary information
From the following article
Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome
Fabian Fernandez, Wade Morishita, Elizabeth Zuniga, James Nguyen, Martina Blank, Robert C Malenka & Craig C Garner
Nature Neuroscience 10, 411 - 413 (2007) Published online: 25 February 2007
doi:10.1038/nn1860
Supplementary Fig. 1
Ts65Dn mice exhibit declarative memory problems, but intact procedural learning.
Supplementary Fig. 2
Chronic but not acute administration of picrotoxin (PTX) normalizes Ts65Dn performance in the novel object recognition task.
Supplementary Table 1
Tabulated discrimination indices (DI's) in the novel object recognition task.
Supplementary Table 2
Picrotoxin (PTX), bilobalide (BB) and pentylenetetrazole (PTZ) do not affect exploration times in the novel object recognition task.
Supplementary Table 3
Tabulated alternation percentages (%) in the spontaneous alternation task.
Supplementary Table 4
Pentylenetetrazole (PTZ) does not affect arm entries in the spontaneous alternation task.
Supplementary Discussion
Potential utility of non-competitive GABAA receptor antagonists for the treatment of cognitive impairment in Down syndrome.
Supplementary Methods
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