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Brief Communication

Nature Neuroscience 10, 414–416 (1 April 2007) | doi:10.1038/nn1871

Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala

Val|[eacute]|rie Doy|[egrave]|re , Jacek D|[eogon]|biec , Marie-H Monfils , Glenn E Schafe & Joseph E LeDoux

When reactivated, memories enter a labile, protein synthesis–dependent state, a process referred to as reconsolidation. Here, we show in rats that fear memory retrieval produces a synaptic potentiation in the lateral amygdala that is selective to the reactivated memory, and that disruption of reconsolidation is correlated with a reduction of synaptic potentiation in the lateral amygdala.