Brief Communication abstract
Nature Neuroscience 10, 417 - 419 (2007)
Published online: 18 March 2007 | doi:10.1038/nn1873
Premotor cortex modulates somatosensory cortex during voluntary movements without proprioceptive feedback
Mark Schram Christensen1,2, Jesper Lundbye-Jensen1,3, Svend Sparre Geertsen1,3, Tue Hvass Petersen1,3, Olaf B Paulson2,4 & Jens Bo Nielsen1,3
Movement perception relies on sensory feedback, but the involvement of efference copies remains unclear. We investigated movements without proprioceptive feedback using ischemic nerve block during fMRI in healthy humans, and found preserved activation of the primary somatosensory cortex. This activation was associated with increased interaction with premotor cortex during voluntary movements, which demonstrates that perception of movements relies in part on predictions of sensory consequences of voluntary movements that are mediated by the premotor cortex.
- Department of Exercise and Sport Sciences, University of Copenhagen, Blegdamsvej 3, Panum Institute 24.6, DK-2200 Copenhagen, Denmark.
- Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Kettegård Allé 30, DK-2650 Hvidovre, Denmark.
- Department of Neuroscience and Pharmacology, Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.
- Neurobiology Research Unit, Department of Neurology, The Neuroscience Centre, Rigshospitalet, building 9201, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
Correspondence to: Mark Schram Christensen1,2 e-mail: markc@drcmr.dk
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