Supplementary information

From the following article

Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory

Susheel Vijayraghavan, Min Wang, Shari G Birnbaum, Graham V Williams & Amy F T Arnsten

Nature Neuroscience 10, 376 - 384 (2007) Published online: 4 February 2007

doi:10.1038/nn1846

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Supplementary Fig. 1

Polar plot representation of the effects of D1 agonist SKF81297 (15nA) on the neuron in Fig 1B.

Supplementary Fig. 2

Statistical analysis of effects of low doses of D1R agonists on spatial spread of PFC neuronal memory activity.

Supplementary Fig. 3

Effects of the D1R antagonist SCH 23390 on delay activity of a PFC neuron.

Supplementary Fig. 4

Example of recovery after D1R agonist induced suppression of neuronal activity.

Supplementary Fig. 5

Population analysis of cAMP blockade preventing neuronal suppression by D1 agonist SKF38393.

Supplementary Fig. 6

Hypothesized model of the physiology of inverted U D1 receptor actions.

Supplementary Fig. 7

Recording area in PFC.

Supplementary Fig. 8

Effects of Na+ (saline) ejection on delay activity in PFC cells.

Supplementary Fig. 9

Comparison of the effects of Na+ ejection and D1 agonist ejection on PFC neuronal firing at various current strengths.

Supplementary Fig. 10

Effects of D1R stimulation on average delay activity adjusted for effects on baseline activity.

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