Supplementary information
From the following article
Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
Susheel Vijayraghavan, Min Wang, Shari G Birnbaum, Graham V Williams & Amy F T Arnsten
Nature Neuroscience 10, 376 - 384 (2007) Published online: 4 February 2007
doi:10.1038/nn1846
Supplementary Fig. 1
Polar plot representation of the effects of D1 agonist SKF81297 (15nA) on the neuron in Fig 1B.
Supplementary Fig. 2
Statistical analysis of effects of low doses of D1R agonists on spatial spread of PFC neuronal memory activity.
Supplementary Fig. 3
Effects of the D1R antagonist SCH 23390 on delay activity of a PFC neuron.
Supplementary Fig. 4
Example of recovery after D1R agonist induced suppression of neuronal activity.
Supplementary Fig. 5
Population analysis of cAMP blockade preventing neuronal suppression by D1 agonist SKF38393.
Supplementary Fig. 6
Hypothesized model of the physiology of inverted U D1 receptor actions.
Supplementary Fig. 8
Effects of Na+ (saline) ejection on delay activity in PFC cells.
Supplementary Fig. 9
Comparison of the effects of Na+ ejection and D1 agonist ejection on PFC neuronal firing at various current strengths.
Supplementary Fig. 10
Effects of D1R stimulation on average delay activity adjusted for effects on baseline activity.
Supplementary Methods
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