1. Vittorio Gallo is at the Center for Neuroscience Research, Children's National Medical Center, Washington, DC 20010, USA. e-mail: vgallo@cnmcresearch.org

Abstract

Two independent groups in this issue report synaptic communication between callosal axons and the NG2-positive glial precursors in the brain. Activity-dependent vesicular glutamate release from axon collaterals triggers AMPA-type currents in the precursors. This phenomenon might be involved in regulation of oligodendrocyte differentiation or remyelination.

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