Brief Communication abstract
Nature Neuroscience 10, 1513 - 1514 (2007)
Published online: 11 November 2007 | doi:10.1038/nn2010
Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA
Matthew E Klein1, Daniel T Lioy1, Lin Ma1, Soren Impey1, Gail Mandel1 & Richard H Goodman1
Both increases and decreases in methyl CpG–binding protein 2 (MeCP2) levels cause neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (miR132). Block of miR132-mediated repression increased MeCP2 and brain-derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of MeCP2 reduced BDNF and miR132 levels in vivo. This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression.
- Vollum Institute, Oregon Health & Science University L-474, 3181 SW Sam Jackson Rd., Portland, Oregon 97239, USA.
Correspondence to: Richard H Goodman1 e-mail: goodmanr@ohsu.edu
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Homeostatic regulation of MeCP2 expression by a CREB-induced microRNANature Neuroscience Brief Communication (01 Dec 2007)
