Article abstract
Nature Neuroscience 10, 1569 - 1577 (2007)
Published online: 18 November 2007 | doi:10.1038/nn2008
Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity
Graziella Di Cristo1,6, Bidisha Chattopadhyaya1,2,6, Sandra J Kuhlman1, Yu Fu1, Marie-Claude Bélanger3, Cai Zhi Wu1, Urs Rutishauser4, Lamberto Maffei5 & Z Josh Huang1
Abstract
Functional maturation of GABAergic innervation in the developing visual cortex is regulated by neural activity and sensory inputs and in turn influences the critical period of ocular dominance plasticity. Here we show that polysialic acid (PSA), presented by the neural cell adhesion molecule, has a role in the maturation of GABAergic innervation and ocular dominance plasticity. Concentrations of PSA significantly decline shortly after eye opening in the adolescent mouse visual cortex; this decline is hindered by visual deprivation. The developmental and activity-dependent regulation of PSA expression is inversely correlated with the maturation of GABAergic innervation. Premature removal of PSA in visual cortex results in precocious maturation of perisomatic innervation by basket interneurons, enhanced inhibitory synaptic transmission, and earlier onset of ocular dominance plasticity. The developmental and activity-dependent decline of PSA expression therefore regulates the timing of the maturation of GABAergic inhibition and the onset of ocular dominance plasticity.
- Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11734, USA.
- Neuroscience Program, State University of New York, Stony Brook, New York 11790, USA.
- Centre Hospitalier Universitaire (CHU) Sainte-Justine – Université de Montréal, 3715 CÂte-Ste-Catherine, Montreal H3T IC5, Canada.
- Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York 10021, USA.
- Instituto di Neurofisiologia del Centro Nazionale della Ricerca, via G. Moruzzi 1, 56124 Pisa, Italy.
- Present addresses: CHU Sainte-Justine – Université de Montréal, Montreal, Quebec, Canada (G.D.C.); Friedrich Miescher Institute, Novartis Research Foundation, Basel, Switzerland (B.C.).
Correspondence to: Z Josh Huang1 e-mail: huangj@cshl.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Synapses, scaling and homeostasis in vivoNature Neuroscience News and Views (01 Aug 2002)
RESEARCH
Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputsNature Neuroscience Brief Communication (01 Nov 2004)
See all 55 matches for Research
