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Brief Communication

Nature Neuroscience 10, 1238–1240 (1 October 2007) | doi:10.1038/nn1974

Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors

Zhiqiang Chen , Sharon G Kujawa & William F Sewell

We report a robust regulation of surface AMPA receptors in mouse auditory neurons, both with application of glutamate receptor agonists in cultured neurons and in response to acoustic stimulation in vivo. The reversible reduction of surface AMPA receptors following acoustic stimulation correlated with changes in acoustic sensitivity.