Brief Communication abstract
Nature Neuroscience 10, 1235 - 1237 (2007)
Published online: 16 September 2007 | doi:10.1038/nn1980
A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth
Sarah Huntwork1 & J Troy Littleton1
Neuronal signaling occurs through both action potential–triggered synaptic vesicle fusion and spontaneous release, although the fusion clamp machinery that prevents premature exocytosis of synaptic vesicles in the absence of calcium is unknown. Here we demonstrate that spontaneous release at synapses is regulated by complexin, a SNARE complex–binding protein. Analysis of Drosophila melanogastercomplexin null mutants showed a marked increase in spontaneous fusion and a profound overgrowth of synapses, suggesting that complexin functions as the fusion clamp in vivo and may modulate structural remodeling of neuronal connections by controlling the rate of spontaneous release.
- The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Building 46, Room 3243, Cambridge, Massachusetts 02139, USA.
Correspondence to: J Troy Littleton1 e-mail: troy@mit.edu
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