Nature Neuroscience
1, 431 - 432 (1998)
doi:10.1038/2147
Calcium tsunamis: do astrocytes transmit cell death messages via gap
junctions during ischemia?Samantha L. Budd
& Stuart A. Lipton
CNS Research Institute, Brigham and Women's
Hospital and Program in Neuroscience at Harvard Medical School, 221 Longwood Avenue, LMRC First Floor, Boston, Massachusetts
02115, USA sbudd@rics.bwh.harvard.edu slipton@rics.bwh.harvard.edu
Apoptosis seems to be a dignified method of cell death, dictated by an
individual cell, but new evidence that astrocytes can send apoptotic signals
to neighboring cells through gap junctions challenges this model and may explain
slowly spreading damage to glia after an ischemic insult.
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