Nature Neuroscience
1, 349 - 351 (1998)
doi:10.1038/1557
Molecular identification of the corticosterone-sensitive extraneuronal
catecholamine transporterDirk Gründemann1, Birgit Schechinger2, Gudrun Rappold2
& Edgar Schömig11
Department of Pharmacology, Im Neuenheimer Feld 366,
University of Heidelberg, 69120 Heidelberg,
Germany
2
Department of Human Genetics, Im Neuenheimer Feld 328,
University of Heidelberg, 69120 Heidelberg,
Germany
Correspondence should be addressed to Dirk Gründemann edgar.schoemig@urz.uni.heidelberg.deCatecholaminergic signaling regulates various physiological functions,
such as blood pressure1 and is implicated in drug dependence,
affective disorders and male aggressive behavior2,
3. The actions
of released catecholamines are terminated by sodium-driven, high-affinity
transporters in the plasma membrane of the releasing neurons4,
5
and by a corticosterone-sensitive, low-affinity, high-capacity extraneuronal
transport system6, originally named uptake2, found
in sympathetically innervated tissues7 and in central nervous
system glia8. Here we report the molecular identification and
pharmacological characterization of the extraneuronal catecholamine transporter,
which is unrelated to the family of sodium-driven neuronal monoamine transporters5.
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