Nature Neuroscience
Close windowclose window
Figure 1

Nature Neuroscience  1, 8 - 9 (1998)

Low rates yield big returns

Lance M. Optican
Fig 1 full size
Figure 1. Many theories of movement learning have been based on the beautiful architecture of the cerebellum, which consists of the cerebellar cortex and the deep cerebellar nuclei (DCN).
The primary output of the cerebellar cortex is provided by the Purkinje cell (PC) that receives two excitatory inputs- climbing fibers (cf) that arise from the inferior olive, and parallel fibers (pf) that arise from the granule cells. Granule cells in turn receive inputs from mossy fibers (mf) that come from many parts of the brain stem and spinal cord. Each PC receives input from only one cf, which climbs up the dendritic tree like ivy and makes thousands of synapses along the way, inducing complex spikes in PCs. In contrast, each PC receives multiple pf inputs, which give rise to simple spikes in the PC. There are also inhibitory interneurons that influence PC output that are not shown here for sake of simplicity.

Close windowclose window
©2007 Nature Publishing Group | Privacy policy