Browse Articles

  • Article |

    SFRP1, an ADAM10 inhibitor, is elevated in the brains of patients with Alzheimer’s disease (AD). Antibody-mediated neutralization of its activity stalls brain alterations and cognitive loss in AD-like mice, supporting SFRP1 as a potential target for disease therapy.

    • Pilar Esteve
    • , Javier Rueda-Carrasco
    • , María Inés Mateo
    • , María Jesús Martin-Bermejo
    • , Jonathan Draffin
    • , Guadalupe Pereyra
    • , África Sandonís
    • , Inmaculada Crespo
    • , Inmaculada Moreno
    • , Ester Aso
    • , Paula Garcia-Esparcia
    • , Estrella Gomez-Tortosa
    • , Alberto Rábano
    • , Juan Fortea
    • , Daniel Alcolea
    • , Alberto Lleo
    • , Michael T. Heneka
    • , José M. Valpuesta
    • , José A. Esteban
    • , Isidro Ferrer
    • , Mercedes Domínguez
    •  & Paola Bovolenta
  • Resource |

    Targeting genes to specific cell types is valuable for basic science and gene therapy. The authors describe a collection of AAVs containing synthetic promoters targeting a broad range of neuronal cell types in mice, non-human primates and humans.

    • Josephine Jüttner
    • , Arnold Szabo
    • , Brigitte Gross-Scherf
    • , Rei K. Morikawa
    • , Santiago B. Rompani
    • , Peter Hantz
    • , Tamas Szikra
    • , Federico Esposti
    • , Cameron S. Cowan
    • , Arjun Bharioke
    • , Claudia P. Patino-Alvarez
    • , Özkan Keles
    • , Akos Kusnyerik
    • , Thierry Azoulay
    • , Dominik Hartl
    • , Arnaud R. Krebs
    • , Dirk Schübeler
    • , Rozina I. Hajdu
    • , Akos Lukats
    • , Janos Nemeth
    • , Zoltan Z. Nagy
    • , Kun-Chao Wu
    • , Rong-Han Wu
    • , Lue Xiang
    • , Xiao-Long Fang
    • , Zi-Bing Jin
    • , David Goldblum
    • , Pascal W. Hasler
    • , Hendrik P. N. Scholl
    • , Jacek Krol
    •  & Botond Roska
  • Resource |

    Using a large task battery spanning motor, cognitive, social and affective domains, this functional MRI (fMRI) study provides a comprehensive functional map of the human cerebellum, along with a comparison to maps derived from anatomy and resting-state fMRI data.

    • Maedbh King
    • , Carlos R. Hernandez-Castillo
    • , Russell A. Poldrack
    • , Richard B. Ivry
    •  & Jörn Diedrichsen
  • Resource |

    Sun et al. built a comprehensive atlas of inputs to major types of GABAergic interneurons in the prefrontal cortex of mice. Through three-dimensional reconstruction of neural morphology, the authors classified input neurons and identified novel neural circuits.

    • Qingtao Sun
    • , Xiangning Li
    • , Miao Ren
    • , Mengting Zhao
    • , Qiuyuan Zhong
    • , Yuqi Ren
    • , Pan Luo
    • , Hong Ni
    • , Xiaoyu Zhang
    • , Chen Zhang
    • , Jing Yuan
    • , Anan Li
    • , Minmin Luo
    • , Hui Gong
    •  & Qingming Luo
  • Article |

    Genetic techniques to manipulate autonomic nerves in a tumor- and fiber-type-specific manner in rodent models of breast cancer reveal that sympathetic nerve denervation or parasympathetic nerve stimulation suppresses breast cancer growth and progression.

    • Atsunori Kamiya
    • , Yohsuke Hayama
    • , Shigeki Kato
    • , Akihiko Shimomura
    • , Takushi Shimomura
    • , Katsumasa Irie
    • , Ryosuke Kaneko
    • , Yuchio Yanagawa
    • , Kazuto Kobayashi
    •  & Takahiro Ochiya
  • Article |

    Parietal neurons encode the information gains that saccades are expected to bring for subsequent actions independently of economic utility, consistent with a boost in neural gain to facilitate the implementation of sampling policies.

    • Mattias Horan
    • , Nabil Daddaoua
    •  & Jacqueline Gottlieb
  • Obituary |

    On April 13, the neuroscience community lost a remarkable scientist and true humanitarian. Paul Greengard, co-recipient of the Nobel Prize in Physiology or Medicine in 2000, Vincent Astor Professor and head of the Laboratory of Molecular and Cellular Neuroscience at the Rockefeller University in New York City, died of an apparent heart attack at age 93. Paul will be remembered for his seminal contributions to neuroscience, for pioneering the field of neuronal signal transduction and for training hundreds of neuroscientists. For anyone who knew Paul it will come as no surprise that up until a few hours before his death, Paul was doing what he liked the best: working on a scientific manuscript.

    • Helen S. Bateup
    • , Myriam Heiman
    •  & Anne Schaefer
  • News & Views |

    The creation of a murine Cre driver specific to CNS capillary pericytes has opened a major bottleneck in brain microvascular research. Using this tool, pericyte loss in the adult brain is shown to induce neuronal loss due to concurrent microcirculatory failure and depletion of the protective trophic factor pleiotrophin.

    • Andrée-Anne Berthiaume
    •  & Andy Y. Shih
  • Article |

    T cell-derived interferon-γ signaling to microglia underlies spatial-learning deficits associated with West Nile virus and Zika virus via the loss of hippocampal presynaptic termini or neurons with elimination of postsynaptic termini, respectively.

    • Charise Garber
    • , Allison Soung
    • , Lauren L. Vollmer
    • , Marlene Kanmogne
    • , Aisling Last
    • , Jasmine Brown
    •  & Robyn S. Klein
  • Article |

    Using pericyte-specific Cre and ablation mouse lines, the authors show that loss of brain pericytes leads to circulatory failure and reduced pleiotrophin causing rapid neuron loss. These findings link pericyte loss to a rapid neurodegeneration cascade.

    • Angeliki M. Nikolakopoulou
    • , Axel Montagne
    • , Kassandra Kisler
    • , Zhonghua Dai
    • , Yaoming Wang
    • , Mikko T. Huuskonen
    • , Abhay P. Sagare
    • , Divna Lazic
    • , Melanie D. Sweeney
    • , Pan Kong
    • , Min Wang
    • , Nelly Chuqui Owens
    • , Erica J. Lawson
    • , Xiaochun Xie
    • , Zhen Zhao
    •  & Berislav V. Zlokovic
  • Article |

    This paper elucidates the mechanism regulating the subcellular localization of UBE3A and demonstrates that abrogation of UBE3A nuclear localization leads to electrophysiological and behavioral impairments in mice and to Angelman syndrome in humans.

    • Rossella Avagliano Trezza
    • , Monica Sonzogni
    • , Stijn N. V. Bossuyt
    • , F. Isabella Zampeta
    • , A. Mattijs Punt
    • , Marlene van den Berg
    • , Diana C. Rotaru
    • , Linda M. C. Koene
    • , Shashini T. Munshi
    • , Jeffrey Stedehouder
    • , Johan M. Kros
    • , Mark Williams
    • , Helen Heussler
    • , Femke M. S. de Vrij
    • , Edwin J. Mientjes
    • , Geeske M. van Woerden
    • , Steven A. Kushner
    • , Ben Distel
    •  & Ype Elgersma
  • Article |

    Using three-dimensional correlative light and electron microscopy of Lewy bodies and Lewy neurites in postmortem brains of Parkinson’s disease patients, researchers show that the major constituents are membranes rather than proteinaceous filaments.

    • Sarah H. Shahmoradian
    • , Amanda J. Lewis
    • , Christel Genoud
    • , Jürgen Hench
    • , Tim E. Moors
    • , Paula P. Navarro
    • , Daniel Castaño-Díez
    • , Gabriel Schweighauser
    • , Alexandra Graff-Meyer
    • , Kenneth N. Goldie
    • , Rosmarie Sütterlin
    • , Evelien Huisman
    • , Angela Ingrassia
    • , Yvonne de Gier
    • , Annemieke J. M. Rozemuller
    • , Jing Wang
    • , Anne De Paepe
    • , Johannes Erny
    • , Andreas Staempfli
    • , Joerg Hoernschemeyer
    • , Frederik Großerüschkamp
    • , Daniel Niedieker
    • , Samir F. El-Mashtoly
    • , Marialuisa Quadri
    • , Wilfred F. J. Van IJcken
    • , Vincenzo Bonifati
    • , Klaus Gerwert
    • , Bernd Bohrmann
    • , Stephan Frank
    • , Markus Britschgi
    • , Henning Stahlberg
    • , Wilma D. J. Van de Berg
    •  & Matthias E. Lauer
  • News & Views |

    Shahmoradian and colleagues report that the structure of Lewy bodies in Parkinson’s disease consists of α-synuclein and lipid vesicle clusters instead of the long-assumed amyloid fibril core. This finding has implications for our understanding of the underlying pathogenesis of synucleinopathies.

    • Tim Bartels
  • Brief Communication |

    A new study reveals that complete loss of TREM2 function or expression of the TREM2R47H Alzheimer’s disease risk variant hinders amyloid-β plaque-associated microglia, leaving peri-plaque neurites susceptible to tau seeding and spreading.

    • Cheryl E. G. Leyns
    • , Maud Gratuze
    • , Sneha Narasimhan
    • , Nimansha Jain
    • , Lauren J. Koscal
    • , Hong Jiang
    • , Melissa Manis
    • , Marco Colonna
    • , Virginia M. Y. Lee
    • , Jason D. Ulrich
    •  & David M. Holtzman
  • Article |

    Chondroitinase injections into monkey spinal cords 4 weeks after hemisection injury increased corticospinal axon growth and corticospinal synapse formation and improved functional outcomes.

    • Ephron S. Rosenzweig
    • , Ernesto A. Salegio
    • , Justine J. Liang
    • , Janet L. Weber
    • , Chase A. Weinholtz
    • , John H. Brock
    • , Rod Moseanko
    • , Stephanie Hawbecker
    • , Roger Pender
    • , Christina L. Cruzen
    • , Jennifer F. Iaci
    • , Anthony O. Caggiano
    • , Andrew R. Blight
    • , Barbara Haenzi
    • , J. Russell Huie
    • , Leif A. Havton
    • , Yvette S. Nout-Lomas
    • , James W. Fawcett
    • , Adam R. Ferguson
    • , Michael S. Beattie
    • , Jacqueline C. Bresnahan
    •  & Mark H. Tuszynski
  • Brief Communication |

    Optogenetics has revolutionized neuroscience, but intracranial illumination can cause off-target effects. Owen et al. identify a temperature-sensitive potassium current that modulates neuronal activity and behavior independent of opsin expression.

    • Scott F. Owen
    • , Max H. Liu
    •  & Anatol C. Kreitzer
  • Article |

    The study reports a genome-wide significant locus for cannabis use disorder, replicating in an independent cohort, and implicates CHRNA2, which encodes an acetylcholine receptor subunit, in the disorder by analyses of genetically regulated gene expression.

    • Ditte Demontis
    • , Veera Manikandan Rajagopal
    • , Thorgeir E. Thorgeirsson
    • , Thomas D. Als
    • , Jakob Grove
    • , Kalle Leppälä
    • , Daniel F. Gudbjartsson
    • , Jonatan Pallesen
    • , Carsten Hjorthøj
    • , Gunnar W. Reginsson
    • , Thorarinn Tyrfingsson
    • , Valgerdur Runarsdottir
    • , Per Qvist
    • , Jane Hvarregaard Christensen
    • , Jonas Bybjerg-Grauholm
    • , Marie Bækvad-Hansen
    • , Laura M. Huckins
    • , Eli A. Stahl
    • , Allan Timmermann
    • , Esben Agerbo
    • , David M. Hougaard
    • , Thomas Werge
    • , Ole Mors
    • , Preben Bo Mortensen
    • , Merete Nordentoft
    • , Mark J. Daly
    • , Hreinn Stefansson
    • , Kari Stefansson
    • , Mette Nyegaard
    •  & Anders D. Børglum
  • Article |

    Microglia are resident immune cells of the CNS. Here the authors show that neurons communicate to microglia via activity-dependent fractalkine and ADAM10 signaling to induce removal of synapses in the brain after sensory loss.

    • Georgia Gunner
    • , Lucas Cheadle
    • , Kasey M. Johnson
    • , Pinar Ayata
    • , Ana Badimon
    • , Erica Mondo
    • , M. Aurel Nagy
    • , Liwang Liu
    • , Shane M. Bemiller
    • , Ki-Wook Kim
    • , Sergio A. Lira
    • , Bruce T. Lamb
    • , Andrew R. Tapper
    • , Richard M. Ransohoff
    • , Michael E. Greenberg
    • , Anne Schaefer
    •  & Dorothy P. Schafer
  • Brief Communication |

    The authors show that decreased synaptic efficacy onto raphe-projecting lateral habenula neurons supports opiate withdrawal-induced sociability deficits, and they demonstrate a role for TNF-α signaling in this process.

    • Kristina Valentinova
    • , Anna Tchenio
    • , Massimo Trusel
    • , Joseph A. Clerke
    • , Arnaud L. Lalive
    • , Stamatina Tzanoulinou
    • , Alessandro Matera
    • , Imane Moutkine
    • , Luc Maroteaux
    • , Rosa C. Paolicelli
    • , Andrea Volterra
    • , Camilla Bellone
    •  & Manuel Mameli
  • News & Views |

    A new study by Owen et al. shows that widely used optogenetic light delivery can heat brain tissue and produce changes in neural activity and behavior in the absence of opsins. How will this finding influence experimental design in the optical age of neuroscience?

    • Daniel F. Cardozo Pinto
    •  & Stephan Lammel
  • Resource |

    Gouwens et al. established a morpho-electrical taxonomy of cell types for the mouse visual cortex via unsupervised clustering analysis of multiple quantitative features from 1,938 neurons available online at the Allen Cell Types Database.

    • Nathan W. Gouwens
    • , Staci A. Sorensen
    • , Jim Berg
    • , Changkyu Lee
    • , Tim Jarsky
    • , Jonathan Ting
    • , Susan M. Sunkin
    • , David Feng
    • , Costas A. Anastassiou
    • , Eliza Barkan
    • , Kris Bickley
    • , Nicole Blesie
    • , Thomas Braun
    • , Krissy Brouner
    • , Agata Budzillo
    • , Shiella Caldejon
    • , Tamara Casper
    • , Dan Castelli
    • , Peter Chong
    • , Kirsten Crichton
    • , Christine Cuhaciyan
    • , Tanya L. Daigle
    • , Rachel Dalley
    • , Nick Dee
    • , Tsega Desta
    • , Song-Lin Ding
    • , Samuel Dingman
    • , Alyse Doperalski
    • , Nadezhda Dotson
    • , Tom Egdorf
    • , Michael Fisher
    • , Rebecca A. de Frates
    • , Emma Garren
    • , Marissa Garwood
    • , Amanda Gary
    • , Nathalie Gaudreault
    • , Keith Godfrey
    • , Melissa Gorham
    • , Hong Gu
    • , Caroline Habel
    • , Kristen Hadley
    • , James Harrington
    • , Julie A. Harris
    • , Alex Henry
    • , DiJon Hill
    • , Sam Josephsen
    • , Sara Kebede
    • , Lisa Kim
    • , Matthew Kroll
    • , Brian Lee
    • , Tracy Lemon
    • , Katherine E. Link
    • , Xiaoxiao Liu
    • , Brian Long
    • , Rusty Mann
    • , Medea McGraw
    • , Stefan Mihalas
    • , Alice Mukora
    • , Gabe J. Murphy
    • , Lindsay Ng
    • , Kiet Ngo
    • , Thuc Nghi Nguyen
    • , Philip R. Nicovich
    • , Aaron Oldre
    • , Daniel Park
    • , Sheana Parry
    • , Jed Perkins
    • , Lydia Potekhina
    • , David Reid
    • , Miranda Robertson
    • , David Sandman
    • , Martin Schroedter
    • , Cliff Slaughterbeck
    • , Gilberto Soler-Llavina
    • , Josef Sulc
    • , Aaron Szafer
    • , Bosiljka Tasic
    • , Naz Taskin
    • , Corinne Teeter
    • , Nivretta Thatra
    • , Herman Tung
    • , Wayne Wakeman
    • , Grace Williams
    • , Rob Young
    • , Zhi Zhou
    • , Colin Farrell
    • , Hanchuan Peng
    • , Michael J. Hawrylycz
    • , Ed Lein
    • , Lydia Ng
    • , Anton Arkhipov
    • , Amy Bernard
    • , John W. Phillips
    • , Hongkui Zeng
    •  & Christof Koch
  • Author Correction |

    • Maisa C. Takenaka
    • , Galina Gabriely
    • , Veit Rothhammer
    • , Ivan D. Mascanfroni
    • , Michael A. Wheeler
    • , Chun-Cheih Chao
    • , Cristina Gutiérrez-Vázquez
    • , Jessica Kenison
    • , Emily C. Tjon
    • , Andreia Barroso
    • , Tyler Vandeventer
    • , Kalil Alves de Lima
    • , Sonja Rothweiler
    • , Lior Mayo
    • , Soufiene Ghannam
    • , Stephanie Zandee
    • , Luke Healy
    • , David Sherr
    • , Mauricio F. Farez
    • , Alexandre Prat
    • , Jack Antel
    • , David A. Reardon
    • , Hailei Zhang
    • , Simon C. Robson
    • , Gad Getz
    • , Howard L. Weiner
    •  & Francisco J. Quintana
  • Brief Communication |

    Lloyd et al. find that regeneration of CNS myelin requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state, revealing new therapeutic targets for neurodegenerative disease.

    • Amy F. Lloyd
    • , Claire L. Davies
    • , Rebecca K. Holloway
    • , Yasmine Labrak
    • , Graeme Ireland
    • , Dario Carradori
    • , Alessandra Dillenburg
    • , Eva Borger
    • , Daniel Soong
    • , Jill C. Richardson
    • , Tanja Kuhlmann
    • , Anna Williams
    • , Jeffrey W. Pollard
    • , Anne des Rieux
    • , Josef Priller
    •  & Veronique E. Miron
  • Article |

    The role of persistent spiking activity in working memory has recently come under debate. Here the authors use biologically realistic recurrent neural networks to explain why the strength of persistent activity can vary markedly between tasks.

    • Nicolas Y. Masse
    • , Guangyu R. Yang
    • , H. Francis Song
    • , Xiao-Jing Wang
    •  & David J. Freedman
  • Author Correction |

    • Joëlle A. Pasman
    • , Karin J. H. Verweij
    • , Zachary Gerring
    • , Sven Stringer
    • , Sandra Sanchez-Roige
    • , Jorien L. Treur
    • , Abdel Abdellaoui
    • , Michel G. Nivard
    • , Bart M. L. Baselmans
    • , Jue-Sheng Ong
    • , Hill F. Ip
    • , Matthijs D. van der Zee
    • , Meike Bartels
    • , Felix R. Day
    • , Pierre Fontanillas
    • , Sarah L. Elson
    • , Harriet de Wit
    • , Lea K. Davis
    • , James MacKillop
    • , Jaime L. Derringer
    • , Susan J. T. Branje
    • , Catharina A. Hartman
    • , Andrew C. Heath
    • , Pol A. C. van Lier
    • , Pamela A. F. Madden
    • , Reedik Mägi
    • , Wim Meeus
    • , Grant W. Montgomery
    • , A. J. Oldehinkel
    • , Zdenka Pausova
    • , Josep A. Ramos-Quiroga
    • , Tomas Paus
    • , Marta Ribases
    • , Jaakko Kaprio
    • , Marco P. M. Boks
    • , Jordana T. Bell
    • , Tim D. Spector
    • , Joel Gelernter
    • , Dorret I. Boomsma
    • , Nicholas G. Martin
    • , Stuart MacGregor
    • , John R. B. Perry
    • , Abraham A. Palmer
    • , Danielle Posthuma
    • , Marcus R. Munafò
    • , Nathan A. Gillespie
    • , Eske M. Derks
    •  & Jacqueline M. Vink
  • Article |

    Namboodiri, Otis et al. reveal that orbitofrontal cortex acquires and maintains a long-term memory of cue–reward associations to guide multiple aspects of behavioral learning, and that it routes select information to a downstream learning center.

    • Vijay Mohan K. Namboodiri
    • , James M. Otis
    • , Kay van Heeswijk
    • , Elisa S. Voets
    • , Rizk A. Alghorazi
    • , Jose Rodriguez-Romaguera
    • , Stefan Mihalas
    •  & Garret D. Stuber
  • Article |

    Different body parts must be coordinated to perform skills. Lemke et al. report that distinct patterns of brain activity emerge during learning related to each body part and conclude that such patterns are refined independently yet function together.

    • Stefan M. Lemke
    • , Dhakshin S. Ramanathan
    • , Ling Guo
    • , Seok Joon Won
    •  & Karunesh Ganguly
  • News & Views |

    Selecting the most rewarding action and performing it accurately are two separable brain functions that are thought to rely upon different neural systems. New evidence suggests that the cerebellum could learn to do both.

    • Javier F. Medina
  • Article |

    Sensory detection of prey triggers hunting actions in predators. Zhao et al. show that the zona incerta integrates prey-related multisensory signals and induces a motivational drive to guide prey detection and promote predatory attack.

    • Zheng-dong Zhao
    • , Zongming Chen
    • , Xinkuan Xiang
    • , Mengna Hu
    • , Hengchang Xie
    • , Xiaoning Jia
    • , Fang Cai
    • , Yuting Cui
    • , Zijun Chen
    • , Lechen Qian
    • , Jiashu Liu
    • , Congping Shang
    • , Yiqing Yang
    • , Xinyan Ni
    • , Wenzhi Sun
    • , Ji Hu
    • , Peng Cao
    • , Haohong Li
    •  & Wei L. Shen
  • Article |

    How does the mammalian brain trigger prey-capture behavior? Shang et al. identify a subcortical circuit that transforms prey-derived sensory cues into predatory attack signals during hunting behavior in mice.

    • Congping Shang
    • , Aixue Liu
    • , Dapeng Li
    • , Zhiyong Xie
    • , Zijun Chen
    • , Meizhu Huang
    • , Yang Li
    • , Yi Wang
    • , Wei L. Shen
    •  & Peng Cao
  • News & Views |

    How to know when to hunt or when to lay low? Surprisingly, new research shows that activity in the medial zona incerta specifically initiates predation in the mouse. The medial zona incerta integrates visual motion and tactile stimulation sent from the intermediate superior colliculus to motivate hunting.

    • Nicole Procacci
    •  & Jennifer L. Hoy
  • Article |

    Synapses of retinal bipolar cells encode contrast through changes in both the frequency and amplitude of release events. The amplitude code contains symbols up to 11 vesicle equivalents and increases the efficiency of information transmission.

    • Ben James
    • , Léa Darnet
    • , José Moya-Díaz
    • , Sofie-Helene Seibel
    •  & Leon Lagnado
  • Article |

    The (G4C2)30+ repeat expansion is the most prominent mutation in familial FTD and ALS. Here the PAF1 complex is identified as a transcriptional regulator of this unique mutation. Data from FTD tissue positive for the C9orf72 mutation support the relevance of this complex in disease.

    • Lindsey D. Goodman
    • , Mercedes Prudencio
    • , Nicholas J. Kramer
    • , Luis F. Martinez-Ramirez
    • , Ananth R. Srinivasan
    • , Matthews Lan
    • , Michael J. Parisi
    • , Yongqing Zhu
    • , Jeannie Chew
    • , Casey N. Cook
    • , Amit Berson
    • , Aaron D. Gitler
    • , Leonard Petrucelli
    •  & Nancy M. Bonini
  • Article |

    Ziegler, Hauser et al. report brain-wide, myelin-related microstructural growth from adolescence to adulthood and show that this longitudinal growth is reduced in the presence of compulsivity and impulsivity traits.

    • Gabriel Ziegler
    • , Tobias U. Hauser
    • , Michael Moutoussis
    • , Edward T. Bullmore
    • , Ian M. Goodyer
    • , Peter Fonagy
    • , Peter B. Jones
    • , Ulman Lindenberger
    •  & Raymond J. Dolan
  • Article |

    Aydin et al. show that the proneural factors Ascl1 and Neurog2 bind to largely non-overlapping sites in the genome, establishing distinct chromatin landscapes that shape the activity of downstream factors during neuronal fate specification.

    • Begüm Aydin
    • , Akshay Kakumanu
    • , Mary Rossillo
    • , Mireia Moreno-Estellés
    • , Görkem Garipler
    • , Niels Ringstad
    • , Nuria Flames
    • , Shaun Mahony
    •  & Esteban O. Mazzoni
  • Article |

    The authors generated a mouse model of C9ORF72-related amyotrophic lateral sclerosis and frontotemporal dementia based on dipeptide repeat proteins and report that defects in mitochondria may contribute to disease pathogenesis.

    • So Yoen Choi
    • , Rodrigo Lopez-Gonzalez
    • , Gopinath Krishnan
    • , Hannah L. Phillips
    • , Alissa Nana Li
    • , William W. Seeley
    • , Wei-Dong Yao
    • , Sandra Almeida
    •  & Fen-Biao Gao
  • Resource |

    Van Hove et al. reveal the diversity of macrophages at the brain’s border regions via single-cell analysis and fate-mapping. This also identified a microglial subset at the surface of the choroid plexus, in direct contact with cerebrospinal fluid.

    • Hannah Van Hove
    • , Liesbet Martens
    • , Isabelle Scheyltjens
    • , Karen De Vlaminck
    • , Ana Rita Pombo Antunes
    • , Sofie De Prijck
    • , Niels Vandamme
    • , Sebastiaan De Schepper
    • , Gert Van Isterdael
    • , Charlotte L. Scott
    • , Jeroen Aerts
    • , Geert Berx
    • , Guy E. Boeckxstaens
    • , Roosmarijn E. Vandenbroucke
    • , Lars Vereecke
    • , Diederik Moechars
    • , Martin Guilliams
    • , Jo A. Van Ginderachter
    • , Yvan Saeys
    •  & Kiavash Movahedi
  • Article |

    Lu et al. report a pathway that reprograms protein quality control under stress. Identified in a Caenorhabditis elegans screen and characterized in mammalian systems, L3MBTL1 and its partner SETD8 modulate proteotoxicity and are deregulated in patients with ALS/FTD.

    • Jiayin Lu
    • , Goran Periz
    • , Yu-Ning Lu
    • , Qing Tang
    • , Yang Liu
    • , Tao Zhang
    • , Yajas Shah
    • , Ravi Thombre
    • , Reham Aljumaah
    • , Weixin Li
    • , Jelena Mojsilovic-Petrovic
    • , Yon Ji
    • , Kenji Johnson
    • , Robert Kalb
    •  & Jiou Wang
  • News & Views |

    The CNS harbors distinct subsets of macrophages, including parenchymal microglia and macrophages residing at border regions (for example, meninges and the choroid plexus). In this issue of Nature Neuroscience, Van Hove and colleagues elegantly demonstrate the diversity and dynamics of non-parenchymal macrophages and identify a unique microglial subtype within the choroid plexus.

    • Sebastian G. Utz
    •  & Melanie Greter