Focus on neurodegenerative diseases

We present a collection of Reviews on recent advances in neurodegenerative disease, highlighting shared mechanisms across diseases and the gaps in our knowledge that still need to be addressed.

Latest Research

  • Article |

    Venniro et al. report that drug-addicted rats reliably choose contact with another rat over drugs, even when group-housed between tests. They also do not show the increase in drug craving that normally occurs during forced abstinence.

    • Marco Venniro
    • , Michelle Zhang
    • , Daniele Caprioli
    • , Jennifer K. Hoots
    • , Sam A. Golden
    • , Conor Heins
    • , Marisela Morales
    • , David H. Epstein
    •  & Yavin Shaham
  • Resource |

    Bienkowski et al. have created a new subregional atlas of the mouse hippocampus that integrates gene expression with anatomical connectivity to reveal the multiscale organization of the hippocampus and its connections throughout the brain.

    • Michael S. Bienkowski
    • , Ian Bowman
    • , Monica Y. Song
    • , Lin Gou
    • , Tyler Ard
    • , Kaelan Cotter
    • , Muye Zhu
    • , Nora L. Benavidez
    • , Seita Yamashita
    • , Jaspar Abu-Jaber
    • , Sana Azam
    • , Darrick Lo
    • , Nicholas N. Foster
    • , Houri Hintiryan
    •  & Hong-Wei Dong
  • Article |

    The authors report TNFα-dependent hyperactivity in cortical microcircuits during remission in a mouse model of multiple sclerosis, a maladaptive response to the immune attack with behavioral changes.

    • Erik Ellwardt
    • , Gautam Pramanik
    • , Dirk Luchtman
    • , Tanja Novkovic
    • , Eduardo Rosales Jubal
    • , Johannes Vogt
    • , Isabelle Arnoux
    • , Christina Francisca Vogelaar
    • , Shibajee Mandal
    • , Melanie Schmalz
    • , Zeke Barger
    • , Inigo Ruiz de Azua
    • , Tanja Kuhlmann
    • , Beat Lutz
    • , Thomas Mittmann
    • , Stefan Bittner
    • , Frauke Zipp
    •  & Albrecht Stroh
  • Review Article |

    Microglia are the sentinels, housekeepers, and defenders of the brain. In this review we consider the immune checkpoints that control microglial functions and discuss how their imbalance and subsequent neuroinflammation leads to neurodegeneration.

    • Suzanne Hickman
    • , Saef Izzy
    • , Pritha Sen
    • , Liza Morsett
    •  & Joseph El Khoury

News & Comment

  • News & Views |

    In this issue of Nature Neuroscience, Menegas et al. demonstrate a role for midbrain dopamine neurons projecting to the tail of the striatum in encoding stimulus novelty and threat avoidance. From this study emerges a model whereby distinct dopaminergic projections to striatum influence behavior along at least two axes, one representing value and one representing threat.

    • Cody A. Siciliano
    • , Fergil Mills
    •  & Kay M. Tye
  • News & Views |

    While the role of protein synthesis in synaptic plasticity and memory is well-established, protein degradation processes have been less studied. A seminal 2003 Nature Neuroscience paper showed that ubiquitin-dependent degradation of synaptic proteins is engaged during activity-regulated synaptic remodeling.

    • Jason D. Shepherd
  • News & Views |

    How we value our own rewards depends on what others have. A new study shows that neurons in the medial prefrontal cortex selectively monitor the value of rewards received by oneself or by another individual, whereas midbrain dopaminergic neurons integrate these values to generate social subjective reward values.

    • Olga Dal Monte
    • , Siqi Fan
    •  & Steve W. C. Chang
  • News & Views |

    The surge in single-cell and single-nucleus RNA-sequencing has raised the question of the value of bulk tissue transcriptomics. Kelley et al. describe an analysis framework by which existing bulk transcriptomic data can be reanalyzed using cell-type-specific data to yield insights into cell-type variation across brain regions and diseases.

    • Vilas Menon
  • News & Views |

    Twenty years ago, 2 studies showed that behavioral experience affects proliferation & survival of newborn neurons in adult hippocampus, suggesting adult neurogenesis as a form of experience-dependent neuroplasticity relevant to memory, emotion, & mental health.

    • Michael R. Drew
    •  & Christine A. Denny

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