Gut response to dietary salt promotes neurovascular and cognitive dysfunction

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News & Comment

  • News & Views |

    Both nucleus accumbens and orexin play clear roles in motivated behavior, but the functions of orexin projections to accumbens are poorly understood. Blomeley et al. show that this pathway, via specific orexin excitation of dopamine D2 receptor–expressing neurons, can inhibit reward seeking and exploratory drive when danger is perceived.

    • Stephen V. Mahler
  • Editorial |

    Neuroscience is not spared from wrestling with gender disparity issues. Progress toward more balanced representation has been slow, but improvement is possible with consistent and focused efforts.

  • News & Views |

    The medial entorhinal cortex contains spatially selective grid cells, whose lattice-like firing patterns are proposed to support path-integration-based navigation. However, direct behavioral evidence has been lacking. Gil et al. disrupt grid cells in a targeted manner, establishing a clear link between grid cell codes and navigation.

    • Caitlin S. Mallory
    •  & Lisa M. Giocomo
  • News & Views |

    New studies provide compelling evidence that the number and length of myelin sheaths generated by oligodendrocytes in the CNS are controlled by local calcium levels, linking axonal activity to individual myelin sheath formation.

    • Robert H. Miller
  • News & Views |

    Super-resolution optical imaging of presynaptic terminals shows that a protein essential to all known forms of neurotransmitter release is clustered in small assemblies that likely correspond to release sites for synaptic vesicle fusion.

    • Timothy A. Ryan
  • Comment |

    As technology advances, whole genome sequencing (WGS) is likely to supersede other genotyping technologies. The rate of this change depends on its relative cost and utility. Variants identified uniquely through WGS may reveal novel biological pathways underlying complex disorders and provide high-resolution insight into when, where, and in which cell type these pathways are affected. Alternatively, cheaper and less computationally intensive approaches may yield equivalent insights. Understanding the role of rare variants in the noncoding gene-regulating genome through pilot WGS projects will be critical to determining which of these two extremes best represents reality. With large cohorts, well-defined risk loci, and a compelling need to understand the underlying biology, psychiatric disorders have a role to play in this preliminary WGS assessment. The Whole Genome Sequencing for Psychiatric Disorders Consortium will integrate data for 18,000 individuals with psychiatric disorders, beginning with autism spectrum disorder, schizophrenia, bipolar disorder, and major depressive disorder, along with over 150,000 controls.

    • Stephan J. Sanders
    • , Benjamin M. Neale
    • , Hailiang Huang
    • , Donna M. Werling
    • , Joon-Yong An
    • , Shan Dong
    • , Goncalo Abecasis
    • , P. Alexander Arguello
    • , John Blangero
    • , Michael Boehnke
    • , Mark J. Daly
    • , Kevin Eggan
    • , Daniel H. Geschwind
    • , David C. Glahn
    • , David B. Goldstein
    • , Raquel E. Gur
    • , Robert E. Handsaker
    • , Steven A. McCarroll
    • , Roel A. Ophoff
    • , Aarno Palotie
    • , Carlos N. Pato
    • , Chiara Sabatti
    • , Matthew W. State
    • , A. Jeremy Willsey
    • , Steven E. Hyman
    • , Anjene M. Addington
    • , Thomas Lehner
    •  & Nelson B. Freimer

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