3D human neuron-astrocyte-microglia triculture model of Alzheimer's disease.

Latest Research

  • Article |

    Maternal stress during pregnancy is a risk factor for neurodevelopmental disorders. Jasarevic and colleagues show that the maternal vaginal microbiota partially mediates the lasting effects of prenatal stress on the gut and hypothalamus in mice.

    • Eldin Jašarević
    • , Christopher D. Howard
    • , Kathleen Morrison
    • , Ana Misic
    • , Tiffany Weinkopff
    • , Phillip Scott
    • , Christopher Hunter
    • , Daniel Beiting
    •  & Tracy L. Bale
  • Article |

    Unpredicted aversive experiences activate DA neurons in dorsal tegmentum; these neurons are important for fear learning. This prediction-error circuit module linking amygdala and dorsal tegmentum enables a solution to an associative learning problem.

    • Florian Groessl
    • , Thomas Munsch
    • , Susanne Meis
    • , Johannes Griessner
    • , Joanna Kaczanowska
    • , Pinelopi Pliota
    • , Dominic Kargl
    • , Sylvia Badurek
    • , Klaus Kraitsy
    • , Arash Rassoulpour
    • , Johannes Zuber
    • , Volkmar Lessmann
    •  & Wulf Haubensak
  • Resource |

    A localized set of mRNA at the synapse facilitates synapse formation and plasticity. The authors show an enrichment of N6-methyladenosine (m6A) modifications of these mRNA at the synapse and link m6A recognition by molecular readers to synaptic function.

    • Daria Merkurjev
    • , Wan-Ting Hong
    • , Kei Iida
    • , Ikumi Oomoto
    • , Belinda J. Goldie
    • , Hitoshi Yamaguti
    • , Takayuki Ohara
    • , Shin-ya Kawaguchi
    • , Tomoo Hirano
    • , Kelsey C. Martin
    • , Matteo Pellegrini
    •  & Dan Ohtan Wang

News & Comment

  • News & Views |

    Protein kinases are key regulators of excitatory synapse plasticity. In this issue, using novel optical reporters of protein kinase C (PKC) activity, Colgan et al. identify PKCα as critical for integrating NMDA receptor and neurotrophin signaling to control dendritic spine structural plasticity, synaptic potentiation, and learning and memory.

    • Mark L. Dell’Acqua
    •  & Kevin M. Woolfrey
  • News & Views |

    Alzheimer’s disease (AD) research is hampered by a lack of models that recapitulate all key disease features. Park et al. introduce a microfluidic device containing a 3D culture of human neurons, astrocytes, and microglia that develop AD-like pathology, revealing a potentially important inflammatory mechanism of neurodegeneration.

    • Christopher M. Henstridge
    •  & Tara L. Spires-Jones
  • News & Views |

    Often overlooked, the paraventricular nucleus of the thalamus is a stress-sensitive region in the midline thalamus essential for stress-induced adaptations. Using cutting edge in vivo monitoring approaches, Beas, Wright et al. identify a circuit by which stress disinhibits the midline thalamus through dopaminergic modulation arising from the locus coeruleus.

    • Kurt M. Fraser
    •  & Patricia H. Janak
  • News & Views |

    The origin of microglia, the resident macrophage population of the CNS, has been a long-standing matter of debate. Here we discuss two seminal studies published in 2007 in Nature Neuroscience that significantly contributed to a better understanding of microglia ontogeny and homeostasis in the adult brain.

    • Florent Ginhoux
    •  & Sonia Garel
  • News & Views |

    New techniques enable simultaneous optogenetic stimulation and calcium imaging from ensembles of tens of neurons in vivo. Improved opsins are localized to the cell body, minimizing spurious activation of the optically unresolvable neuropil. Two-photon light pulses are sculpted in space, time, and wavelength to efficiently target the desired cells.

    • Adam E. Cohen
    •  & Samouil L. Farhi
  • News & Views |

    In 2004, Weaver et al. published evidence in Nature Neuroscience for the lasting epigenetic impact of maternal care within the hippocampus of rat offspring. This conceptual and methodological leap contributed to the evolution of environmental and behavioral epigenetics and continues to inspire challenging questions about genes, environments, and their legacy.

    • Frances A. Champagne

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