Nature Neuroscience's 20th Anniversary

Our May issue marks Nature Neuroscience’s 20th anniversary. We reflect here on how the journal has evolved and what’s to come.

Latest Research

  • Brief Communication |

    mTORC1 was posited as required for hippocampal mGluR-LTD at CA1 synapses based on its pharmacological inhibition with rapamycin. Using molecular genetics, the authors show that mTORC2 but not mTORC1 is required for mGluR-LTD and associated behaviors.

    • Ping Jun Zhu
    • , Chien-Ju Chen
    • , Jacqunae Mays
    • , Loredana Stoica
    •  & Mauro Costa-Mattioli
  • Article |

    Khan et al. simultaneously measured activity from excitatory cells and three classes of inhibitory interneurons in visual cortex and show that learning differentially shapes the stimulus selectivity and interactions of multiple cell classes.

    • Adil G. Khan
    • , Jasper Poort
    • , Angus Chadwick
    • , Antonin Blot
    • , Maneesh Sahani
    • , Thomas D. Mrsic-Flogel
    •  & Sonja B. Hofer
  • Brief Communication |

    The neuropeptide CRH is believed to induce aversive, stress-like behavioral responses. Here the authors describe a distinct population of CRH neurons in the extended amygdala that act to suppress anxiety by positively modulating dopamine release.

    • Nina Dedic
    • , Claudia Kühne
    • , Mira Jakovcevski
    • , Jakob Hartmann
    • , Andreas J. Genewsky
    • , Karina S. Gomes
    • , Elmira Anderzhanova
    • , Max L. Pöhlmann
    • , Simon Chang
    • , Adam Kolarz
    • , Annette M. Vogl
    • , Julien Dine
    • , Michael W. Metzger
    • , Bianca Schmid
    • , Rafael C. Almada
    • , Kerry J. Ressler
    • , Carsten T. Wotjak
    • , Valery Grinevich
    • , Alon Chen
    • , Mathias V. Schmidt
    • , Wolfgang Wurst
    • , Damian Refojo
    •  & Jan M. Deussing
  • Perspective |

    In this Perspective, Josh Berke discusses recent developments in the study of dopamine function. He proposes a model that explains how dopamine can serve as both a learning signal and as a critical modulator of motivated decision-making.

    • Joshua D. Berke
  • Article |

    The authors revise the classical view that homeostasis of neuronal activity is achieved by negative firing rate feedback: during sensory deprivation, homeostasis occurs via the sliding threshold, which acts via firing patterns rather than rates.

    • Michelle C. D. Bridi
    • , Roberto de Pasquale
    • , Crystal L. Lantz
    • , Yu Gu
    • , Andrew Borrell
    • , Se-Young Choi
    • , Kaiwen He
    • , Trinh Tran
    • , Su Z. Hong
    • , Andrew Dykman
    • , Hey-Kyoung Lee
    • , Elizabeth M. Quinlan
    •  & Alfredo Kirkwood

News & Comment

  • News & Views |

    In 2004, Weaver et al. published evidence in Nature Neuroscience for the lasting epigenetic impact of maternal care within the hippocampus of rat offspring. This conceptual and methodological leap contributed to the evolution of environmental and behavioral epigenetics and continues to inspire challenging questions about genes, environments, and their legacy.

    • Frances A. Champagne
  • News & Views |

    Synaptic connections adapt homeostatically to changes in experience to maintain optimal circuit function. A study demonstrates that different forms of synaptic homeostasis respond to distinct aspects of circuit activity, suggesting that neurons can gauge and adapt to the both the quality and quantity of circuit activity.

    • Kimberly M. Huber
  • News & Views |

    Recurring bursts of thalamocortical cells were thought to be indispensable in driving absence seizures. A new study demonstrates that bursts from inhibitory thalamic reticular neurons are crucial instead. Reticular bursts are driven by cortical inputs and govern precise timing of thalamocortical cell activity during seizures.

    • László Acsády
  • News & Views |

    The behavioral state of a human or animal can dramatically alter how information is processed in its neural circuits. Albergaria et al. show that locomotion enhances the performance of a cerebellum-dependent behavior. The results provide new constraints on how information is represented there to support learning.

    • Jennifer L. Raymond
  • News & Views |

    Epidemiology and animal research have shown that the offspring of mothers who experience inflammation during pregnancy are at increased risk for psychopathology. A human study links a mother’s inflammation during pregnancy to her newborn’s functional brain organization and the child’s working memory two years later.

    • Monica D. Rosenberg

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