Practice Point

Nature Clinical Practice Urology (2008) 5, 414-415
doi:10.1038/ncpuro1149  
Received 6 February 2008 | Accepted 29 April 2008 | Published online: 24 June 2008

Which treatment should patients with high-risk T1G3 bladder cancer receive?

George J Huang* and John P Stein

Correspondence *Keck School of Medicine, Department of Urology, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA

Email
 georgejh@usc.edu

This article has no abstract so we have provided the first paragraph of the full text.

The management of T1G3 bladder cancer is one of the most difficult clinical challenges faced by urologists. Unfortunately, no clinical trials to date have compared long-term results from patients who undergo immediate or early cystectomy with results from patients who receive initial conservative management with intravesical BCG after transurethral resection, and proceed to cystectomy only in the event of clear progression to muscle involvement (T2). This thoughtful study pools together currently available data from published literature and expert opinion (with their respective limitations and flaws), employing a Markov model to estimate the LE and QALE for patients who undergo one of the two treatments.

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