Table of contents
July 2008 Volume 5 No 7
Editorial
Research Highlights
Optimum management of emphysematous pyelonephritis: a systematic review
352The poppy-seed test is a cheap and accurate diagnostic tool for colovesical fistula
352DNA hypomethylation increases the risk of bladder cancer
352Restoration of the penis after accidental amputation during circumcision
353Factors that influence patients' participation in prostate cancer trials
353Adding antifibrinolytics to BCG instillations might enhance their antitumor efficacy
354Does routine PSA testing decrease prostate cancer mortality?
354IMP3 is a promising biomarker in urological cancers
355Practice Points
Is the Phoenix definition superior to ASTRO for predicting clinical outcomes in prostate cancer?
356doi:10.1038/ncpuro1126 | Full Text | PDF (126K)
Should holmium laser enucleation be the new gold standard for bladder outlet obstruction caused by BPH?
358doi:10.1038/ncpuro1129 | Full Text | PDF (127K)
What is the clinical significance of ipsilateral renal lesions during nephron-sparing surgery?
360doi:10.1038/ncpuro1130 | Full Text | PDF (124K)
Nomogram for predicting survival in men with clinically localized prostate cancer who do not undergo definitive therapy
362doi:10.1038/ncpuro1131 | Full Text | PDF (127K)
Is Mohs micrographic surgery a safe and effective treatment option in patients with penile carcinoma?
364doi:10.1038/ncpuro1132 | Full Text | PDF (127K)
Viewpoint
Do we need more nomograms for predicting outcomes in patients with prostate cancer?
366In this Viewpoint article by Professor Kattan, the author discusses methods for predicting outcomes in patients with prostate cancer, the predictive accuracy of these methods, and why, despite the large number of nomograms already developed, further nomograms are still needed for predicting outcomes in patients with prostate cancer.
doi:10.1038/ncpuro1128 | Full Text | PDF (115K)
Reviews
Bladder-sparing therapy for muscle-infiltrating bladder cancer
368Radical cystectomy is the preferred treatment for nonmetastatic muscle-infiltrating bladder cancer, but several researchers have proposed the use of bladder-sparing approaches. In this Review, Pansadoro and Emiliozzi discuss a variety of possible bladder-sparing approaches and the evidence supporting their use.
doi:10.1038/ncpuro1145 | Full Text | PDF (197K)
Statins and prostate cancer prevention: where we are now, and future directions
376Many experimental studies have reported that statins, cholesterol-lowering drugs, inhibit the growth of prostate cancer cells. In this Review, Murtola and colleagues look at the current evidence on the use of statins in the prevention of prostate cancer.
doi:10.1038/ncpuro1146 | Full Text | PDF (276K)
Testosterone deficiency: a common, unrecognized syndrome
388The signs and symptoms of testosterone deficiency can be nonspecific, and can vary according to patient age and the presence of comorbid illnesses, thereby making diagnosis of the disorder difficult. In this Review, Tostain and Blanc highlight the problems and solutions in diagnosing testosterone deficiency by looking at the signs and symptoms, diagnostic tests, and epidemiology of the disorder.
doi:10.1038/ncpuro1167 | Full Text | PDF (240K)
Case Studies
A case of synchronous bilateral testicular seminoma
397The optimum management of patients with low-stage seminoma remains a matter of debate. Here, Resnick et al. detail the case of a 51-year-old man who was diagnosed with bilateral stage I testicular seminoma. The authors discuss the management of bilateral disease, addressing the implications of surgical castration and the possibility of testis-sparing approaches to treatment.
doi:10.1038/ncpuro1133 | Full Text | PDF (175K)
A case of relapsing secondary bladder adenocarcinoma after right colonic cancer
403Distinguishing primary bladder adenocarcinoma from metastatic colorectal cancer represents a diagnostic challenge; however, a correct diagnosis can prevent the patient from receiving inappropriate treatment. Here, Izzo et al. use the case of a 71-year-old woman to highlight important issues in the diagnosis of these bladder neoplasms, with particular focus on the role of immunohistochemistry.
doi:10.1038/ncpuro1155 | Full Text | PDF (159K)
