PSA velocity does not aid long-term prediction of prostate cancer incidence
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Elevated serum prostate-specific antigen (PSA) levels can indicate the presence of prostate cancer, although PSA levels are also elevated in some non-malignant conditions, which affects the reliability of prostate cancer prediction. PSA levels rise sharply in patients with aggressive prostate cancer, and a recent study suggested that the rate of increase (PSA velocity) could predict life-threatening prostate cancer 10–15 years before diagnosis. Ulmert and colleagues evaluated data from the Malmö Preventative Medicine population-based study to compare the accuracy of a single PSA measurement versus PSA velocity in the long-term prediction of prostate cancer diagnosis.
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