Is there a relationship between urinary tract infection, vesicoureteral reflux and renal damage in children?
Steve S Kim and Douglas A Canning*
Correspondence *Division of Urology, Children's Hospital of Philadelphia, 3rd Floor Wood Building, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
Email canning@email.chop.edu
This article has no abstract so we have provided the first paragraph of the full text.
For the past 40 years, the treatment of children with VUR has been based upon the presumption that preventing febrile UTIs by chemoprophylaxis, or preventing microbial access to the renal parenchyma by surgery, reduces the likelihood of renal scarring.1 We have learned, however, that the relationship between VUR and renal scarring is not as clear as we thought, and we do not yet know how best to manage children with VUR or, more importantly, how to identify those children at the highest risk for developing renal injury as a result of infection.
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