Table of contents
April 2008 Volume 5 No 4
Editorial
Viewpoints
How should PSA screening efforts be focused to prevent underdiagnosis and overdiagnosis of prostate cancer?
172In this Viewpoint article by Pelzer and Horninger, the authors describe a screening strategy for preventing the underdiagnosis of clinically relevant prostate cancer and the overdiagnosis of clinically insignificant disease. The authors argue that the ultimate goal of screening should be to detect biologically consequential disease sufficiently early to allow treatment for cure.
doi:10.1038/ncpuro1051 | Full Text | PDF (100K)
Surgical therapy for the treatment of erectile dysfunction
174This Viewpoint article by Siddiqi and Lewis discusses the role of surgical therapy for the treatment of erectile dysfunction. The article explains why surgical therapy will likely always remain an option for specific patients, regardless of whether or not gene therapy is approved for erectile dysfunction treatment.
Research Highlights
Men with ED have an increased risk of developing Parkinson's disease
176Successful use of the appendix for ureteral replacement: report of 10 pediatric cases
176A low PSA level does not always indicate favorable prognosis
176Successful endoscopic VUR treatment improves children's quality of life
177Antioxidants help to reduce short-term damage induced by ESWL
177Surgical removal of testicular remnants in patients with congenital anorchia
178Plasmakinetic resection of the prostate has advantages over transurethral resection
178Palliative care for patients with urological cancers
179Novel technique halves warm ischemia time during laparoscopic partial nephrectomy
179Treatment and complications of diabetes affect risk of prostate cancer
180Addition of probiotic agent to chemotherapy delays recurrence of bladder cancer
180Time to biochemical failure predicts distant metastases and prostate-cancer-specific mortality
181Practice Points
Does the Deflux® procedure reduce the incidence of urinary tract infections in children with vesicoureteral reflux?
182doi:10.1038/ncpuro1080 | Full Text | PDF (104K)
Is androgen suppression therapy associated with early onset of fatal myocardial infarction?
184doi:10.1038/ncpuro1076 | Full Text | PDF (102K)
Does antimicrobial prophylaxis affect recurrent urinary tract infections and bacterial resistance in children?
186doi:10.1038/ncpuro1053 | Full Text | PDF (103K)
Is duloxetine safe and effective for the treatment of overactive bladder?
188doi:10.1038/ncpuro1077 | Full Text | PDF (104K)
Should hypogonadal men who are suboptimally responsive to testosterone gel switch to another gel preparation?
190doi:10.1038/ncpuro1057 | Full Text | PDF (101K)
Predictors of biochemical progression-free survival in men who receive radiation therapy after prostatectomy
192doi:10.1038/ncpuro1055 | Full Text | PDF (102K)
Reviews
The evolution of midurethral slings
194Sling techniques to treat female urinary stress incontinence began as invasive reappropriations of muscle. This therapy has, however, evolved into a safe and efficacious approach, for which many types of synthetic sling are now commercially available, each with its own particular characteristics. This Review tracks the evolution of this therapy and discusses current outcomes.
doi:10.1038/ncpuro1052 | Full Text | PDF (161K)
Live donor nephrectomy for kidney transplantation
203As the requirement for organs by patients with end-stage renal disease outstrips the size of the donor pool, new sources for kidney donations must be sought. In this Review, the authors discuss the medical, surgical and particularly the psychosocial features of programs aimed at expanding the availability of living donations.
doi:10.1038/ncpuro1047 | Full Text | PDF (144K)
Medical management of lower urinary tract symptoms in men: current treatment and future approaches
211Men with lower urinary tract symptoms frequently do not seek medical advice. For those who do, the traditional view of a solely prostatic origin might hinder management, since growing evidence suggests an important role for nonprostatic causes. This Review clarifies terminology for symptoms and causes and presents an overview of the available medical therapies.
doi:10.1038/ncpuro1060 | Full Text | PDF (154K)
Case Studies
A case of spermatic cord teratoma in low-stage testicular cancer managed by surveillance
220In this Case Study, Subramanian et al. present a patient who underwent orchiectomy for low-stage nonseminomatous germ cell tumor of the testis. The patient opted for management by surveillance, and subsequently developed a recurrent teratoma of the spermatic cord. The case illustrates the importance of combining imaging and tumor marker measurement in surveillance protocols.
doi:10.1038/ncpuro1048 | Full Text | PDF (218K)
A case of iliac-artery–ureteral fistula managed with a combined endoscopic approach
225The iliac-artery–ureteral fistula is a rare, but potentially lethal entity. In this Case Study by Gallo et al. the case of a 66-year-old man who presented with hematuria is used to illustrate the successful diagnosis and management of this condition using only endoscopic techniques.
doi:10.1038/ncpuro1059 | Full Text | PDF (311K)
