Table of contents
February 2007 Volume 4 No 2
February's Special Supplement
This month's issue of Nature Clinical Practice Urology comes with a special supplement focusing on the multidisciplinary management of bone complications in prostate cancer and optimizing outcomes of bisphosphonate therapy. Subscribers to the journal can view it now online.
Editorial
Viewpoint
Mapping studies and modified templates in nonseminomatous germ cell tumors
60This Viewpoint discusses the concept of retroperitoneal surgical templates for lymph node dissection in patients with nonseminomatous germ cell tumors. The author evaluates the benefits and limitations of this approach and argues that the use of modified templates could increase the risk of unresected disease, leading to relapse, repeat surgery, and inferior survival.
Research Highlights
Nerve-sparing cystectomy helps preserve sexual and urinary function
62Using helical CT to choose the appropriate surgery for RCC
63Targeting germ-cell adhesion in the pursuit of a male contraceptive
64Long-term outcomes of endopyelotomy and pyeloplasty are worse than expected
64A new 
1A-adrenoceptor-selective antagonist for treating benign prostatic hyperplasia
64Feedback transurethral microwave thermotherapy treats BPH effectively
65Long-term -adrenergic-antagonist treatment alleviates symptoms of CP/CPPS
65Adjuvant radiotherapy benefits men with locally advanced prostate cancer
66Combination therapy for men with lower urinary tract symptoms
67Practice Points
Does radical prostatectomy provide a survival benefit as primary treatment for high-grade prostate cancer?
68What is the best treatment modality for children with renal stones of 1–2 cm diameter?
70Promise for patients with metastatic renal cell carcinoma
72Antiangiogenic therapy in renal cell carcinoma: from concept to reality
74Does periprostatic nerve block with local anesthetic reduce pain during prostate biopsy?
76Can a restaging transurethral resection predict early progression in patients with superficial bladder cancer?
78Reviews
Biologic agents as adjunctive therapy for prostate cancer: a rationale for use with androgen deprivation
82Androgen deprivation therapy is a proven treatment for prostate cancer, but it can trigger biochemical events that might cause the cancer to progress to androgen-independent disease. This Review examines the mechanisms and cellular pathways involved in the change from androgen-dependent to androgen-independent prostate cancer. The authors discuss the pathophyisologic changes that are induced by androgen deprivation in patients with prostate cancer, highlighting potential targets for future treatments.
doi:10.1038/ncpuro0700 | Full Text | PDF (338K)
The medical management of Peyronie's disease
95There is no established first-line treatment for Peyronie's disease and treatment selection should be directed by a combination of the extent and type of penile deformity, symptoms and disease progression. In this Review the authors discuss the numerous medical treatments that are available for the treatment of Peyronie's disease and introduce a treatment algorithm based on a number of clinical characteristics.
doi:10.1038/ncpuro0729 | Full Text | PDF (248K)
Mechanisms of Disease: hereditary leiomyomatosis and renal cell cancer—a distinct form of hereditary kidney cancer
104Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an inherited disease characterized by skin and uterine leiomyomas, and kidney tumors that are often aggressive. In this Review the authors discuss the etiology of this inherited kidney cancer and the diagnosis and management of affected families. The genetic changes underlying HLRCC and pathophysiological mechanisms behind the development of this disease are also reviewed.
doi:10.1038/ncpuro0711 | Full Text | PDF (311K)
Case Study
A case of prostatitis due to Burkholderia pseudomallei
111doi:10.1038/ncpuro0713 | Full Text | PDF (286K)
