Dose–response in external-beam radiotherapy for prostate cancer: the evidence grows
R Alex Hsi* and John Corman
Correspondence *Virginia Mason Medical Center, 1100 9th Avenue CB-RO, Seattle, WA 98101, USA
Email ronrah@vmmc.org
This article has no abstract so we have provided the first paragraph of the full text.
Dose escalation has been an area of great interest in radiation oncology for the past 15 years. This approach is based on the hypothesis that higher doses of radiotherapy will result in improved tumor control. Techniques such as 3D-CRT, intensity-modulated radiation therapy and, more recently, image-guided radiation therapy, have improved our ability to target the tumor, spare normal tissues, and thus safely increase the radiation dose. Clinical trials have investigated the benefit of dose escalation at many different disease sites, although only a small number of these trials have supported its use.
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