The role of hormone replacement therapy in healthy elderly men
Paul J Jenkins
Correspondence Department of Endocrinology, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK
Email p.j.jenkins@qmul.ac.uk
This article has no abstract so we have provided the first paragraph of the full text.
Secreted by the pituitary gland, GH is a potent anabolic and anticatabolic agent, exerting positive effects on nitrogen retention either by direct actions, or via IGF1. A biphasic role for the GH–IGF1 axis in normal physiology has recently been clarified. IGF1 levels at the high end of the age-corrected normal range are associated with increased incidences of a number of malignancies, including, prostate, colon, and premenopausal breast cancer.1 Conversely, IGF1 levels at the low end of the normal range are associated with an increased risk of coronary heart disease.2
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Is breast cancer a potential side effect of GH treatment?Nature Medicine News and Views (01 Oct 1997)