Table of contents
September 2005 Volume 2 No 9
Editorial
Viewpoint
Interpreting data from randomized trials: the Scandinavian prostatectomy study illustrates two common errors
404Statistical analysis is an essential part of clinical practice, since the very concept of evidence-based medicine hinges on sound interpretation of clinical data. Using the Scandinavian prostatectomy versus watchful waiting study as a practical example, Andrew Vickers presents two common errors: accepting the null hypothesis and misinterpreting the lower statistical power of overall versus cancer-specific survival, and warns of the dangers of forgetting these basic principles.
Research Highlights
Propionibacterium acnes linked with prostatic inflammation and carcinogenesis
406Accuracy of prostate-specific antigen testing for prostate cancer
406New treatment strategy for metastatic renal cell carcinoma
406Caution against using silicone mesh for sacrocolpopexy
407Treatment of bladder outflow obstruction for small prostates
407Improving treatment of erectile dysfunction in cardiac patients
408Postoperative comparison of vaginal and abdominal surgery for uterovaginal prolapse
409Tamsulosin improves effectiveness of ESWL for renal stones
409Losing a few pounds can reduce weekly incontinence episodes by half
409Interstitial cystitis/chronic pelvic pain syndrome is not caused by infection
410Nonsteroidal anti-inflammatory drugs and prostate cancer risk
410Overlap of chronic pelvic pain disorders and neural cross-talk
411
receptor type 2 gene in prostate cancerPractice Points
Radical prostatectomy versus watchful waiting for early prostate cancer: finally, an answer
412Do repeat injections of botulinum toxin type A for detrusor overactivity lead to resistance?
414Can clinically localized prostate cancer be managed conservatively?
416Can pediatric dysfunctional voiding be treated with a short course of pelvic-floor-muscle training with biofeedback?
418Is a combination of gemcitabine and docetaxel effective in advanced urothelial carcinoma?
420Does finasteride compromise the prognostic value of Gleason grading in men with prostate cancer?
422Reviews
The etiology and management of premature ejaculation
426Premature ejaculation (PE) has a number of known causes, and the definition of what constitutes PE can differ. Several factors are used to assess the presence and extent of PE. Chris McMahon discusses the etiology and management of PE, and highlights the importance of selecting treatments that are appropriate to the cause of the condition
doi:10.1038/ncpuro0293 | Full Text | PDF (547K)
Magnetic resonance imaging and magnetic resonance spectroscopic imaging of prostate cancer
434In this review, Renata Huzjan and colleagues discuss the utility of MRI and magnetic resonance spectroscopic imaging (MRSI) in the diagnosis and management of prostate cancer. MRI and MRSI provide important information on the extent, location and characteristics of tumors that is invaluable in pretreatment decision making. In order to fully exploit these techniques, a multidisciplinary approach is essential.
doi:10.1038/ncpuro0296 | Full Text | PDF (460K)
From coagulation to enucleation: the use of lasers in surgery for benign prostatic hyperplasia
443A number of different surgical techniques are used for the treatment of benign prostatic hyperplasia(BPH). This article by Liam Wilson and Peter Gilling reviews the different types of lasers available and their applications in ablation, coagulation and enucleation of the hyperplastic prostate for treating BPH.
doi:10.1038/ncpuro0276 | Full Text | PDF (125K)
Therapy insight: priapism associated with hematologic dyscrasias
449Priapism, particularly ischemic priapism, is uncommon in the general male population, but frequently occurs in men with hematologic dyscrasias such as sickle cell disease. In this review, Arthur Burnett focuses on the management of ischemic priapism, and stresses the need for prompt treatment in order to preserve erectile function in this group of men.
doi:10.1038/ncpuro0277 | Full Text | PDF (251K)
