Table of contents
June 2005 Volume 2 No 6
Viewpoint
Artificial neural networks: has the time come for their use in prostate cancer patients?
262Artificial neural networks (ANNs) have been developed for various applications in prostate cancer management, but their ability to perform in this setting remains controversial. In this Viewpoint, authors from the University Hospital Charité present the case for ANNs, and argue that urologists should be using these tools in clinical decision-making.
Research Highlights
The natural progression of conservatively treated clinically localized prostate cancer
264Biofeedback physical therapy for chronic pelvic pain syndrome
264Inhibition of HER2 tyrosine kinase disrupts androgen-receptor functioning
264Diagnosis of azoospermia: effects of semen processing
265Intravesical immunotherapy: adverse effects on spermatogenesis
265Penile modeling for erectile dysfunction in Peyronie's disease
266Botulinum A toxin for neurogenic detrusor overactivity: sustained efficacy with repeated dosing
267Distal ureteric stone removal in children: comparison of procedures
267Hand–eye coordination: video games and laparoscopic surgery
268Vigorous physical activity slows progression of prostate cancer in older men
268Biochemical failure following prostate cancer treatment
269Practice Points
A novel surgical technique for the management of Peyronie's disease
270Do false-positive screening results affect screening behavior for prostate cancer?
272Does catheter size affect pressure–flow studies in women with lower urinary tract symptoms?
274Can tamoxifen or anastrozole prevent bicalutamide-induced gynecomastia and breast pain in prostate cancer?
276Is patient reporting of interstitial cystitis symptoms comparable between two disease-specific indices?
278Reviews
Therapy Insight: sexual and bladder dysfunction associated with diabetes mellitus
282Diabetes mellitus is associated with a number of different vascular and neurologic problems that can lead to the development of bladder dysfunction, erectile dysfunction and retrograde ejaculation. This review by Domenico Fedele examines the mechanisms that lead to the development of these urologic problems in patients with diabetes, and discusses appropriate treatment and management options.
doi:10.1038/ncpuro0211 | Full Text | PDF (151K)
Mechanisms of Disease: new insights into the cellular and molecular pathology of Peyronie's disease
291Hitherto-neglected investigation of processes that underlie the characteristic feature of Peyronie's disease—deposition of fibrotic plaques in the penile tunica albuginea—has been kick-started by the recent development of two rat models. This update of new data is framed around the hypothesis that Peyronie's plaques are a product of perturbed interplay between profibrotic and antifibrotic factors, induced by trauma.
doi:10.1038/ncpuro0201 | Full Text | PDF (170K)
Case Studies
Management of clinically localized prostate cancer by radical prostatectomy followed by watchful waiting
298doi:10.1038/ncpuro0210 | Full Text | PDF (422K)
Locally advanced prostate cancer treated with radiotherapy and androgen deprivation
304doi:10.1038/ncpuro0212 | Full Text | PDF (107K)
