-Catenin in the race to fracture repair: in it to Wnt
David Silkstone, Helen Hong and Benjamin A Alman*
Correspondence *Program in Developmental and Stem Cell Biology, Hospital for Sick Children and University of Toronto, Toronto, Ontario M5G 1X8, Canada
Email benjamin.alman@sickkids.ca
The canonical Wnt/
-catenin signaling pathway regulates multiple biological events, including embryonic bone development and fracture repair. In this Review, the authors discuss the role of this pathway in fracture repair at the molecular, cellular and physiological levels, and its potential as a therapeutic target.
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