Osteoimmunology: a new area of rheumatology research
Peter E Lipsky
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Growing awareness of the close links between the immune and skeletal systems has stimulated development of a new field: osteoimmunology (Walsh MC et al. [2006], Annu Rev Immunol 24: 33–63; Takayanagi H [2007], Nat Rev Immunol 7: 292–304). This discipline generally focuses on three main topics. The first relates to developmental issues, especially the potential role of bone in the development of the immunohemopoietic system; less attention has been devoted to the reciprocal relationship, because initial skeletogenesis seems to occur independently of the immune system. The second focus relates to the influence of the immune system on the skeletal system, and vice versa, during homeostasis, whereas the third area of focus concerns the role of the immune system in bone pathology and the potential involvement of bone in immune system dysfunction.
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