Can corticosteroid therapy alter the course of nephritis in children with Henoch–Schönlein purpura?
Jae Il Shin and Jae Seung Lee*
Correspondence *Department of Pediatrics, Yonsei University College of Medicine, Severance Children's Hospital, 134 Shinchon-Dong Seodaemun-Ku, 120-752, CPO Box 8044, Seoul, South Korea
Email jsyonse@yumc.yonsei.ac.kr
This article has no abstract so we have provided the first paragraph of the full text.
In this randomized, double-blind, placebo-controlled trial by Ronkainen and colleagues, the researchers demonstrated that a 1 mg/kg/day dose of early prednisone therapy was effective in reducing the severity of abdominal and joint symptoms in patients with HSP. The authors also demonstrated that early prednisone therapy is effective in altering the course—i.e. reducing the severity—of renal involvement in these patients, although the incidence of nephritis was not influenced by steroid therapy.
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