Oligonucleotide IRS 954 might represent a novel therapy for SLE
This article has no abstract so we have provided the first paragraph of the full text.
In the autoimmune disease systemic lupus erythematosus (SLE), stimulation of Toll-like receptors (TLR) 7 and 9 by self nucleic acids is postulated to induce plasmacytoid dendritic cells (PDCs) to overproduce interferon-
, a key cytokine in the pathogenesis of SLE. TLR7 and TLR9 are also thought to be involved in B-cell-mediated production of autoantibodies specific to nucleic acids, thereby triggering and then promoting SLE.
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