The cellular interplay that underlies the synovial inflammatory process in RA
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Results from animal models of rheumatoid arthritis (RA) suggest that T-helper 17 (TH17) cells, CD4+ T cells that secrete interleukin 17, have a key role in the progression of the disease. To understand the process more fully, Hirota et al. searched for cell-surface molecules specifically expressed by TH17 cells to identify which molecules might be responsible for their migration to joint tissue.
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