Research Highlights

Nature Clinical Practice Rheumatology (2008) 4, 116
doi:10.1038/ncprheum0711  

The CD40/CD40L system might have a role in inducing skin lesions in patients with SCLE

This article has no abstract so we have provided the first paragraph of the full text.

Subacute cutaneous lupus erythematosus (SCLE), an autoimmune-mediated disease that is characterized by widespread hardening of the skin, is triggered by various environmental factors, including ultraviolet light. The CD40/CD40 ligand (CD40L) costimulatory system, which amplifies immune responses and can induce inflammation, is believed to have a role in skin manifestations of other autoimmune diseases, for example discoid lupus erythematosus (DLE). Caproni and colleagues, therefore, studied the expression of CD40 and CD40L in skin lesions of patients with SCLE.

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