Primer: mechanisms of immunologic tolerance
Nevil J Singh and Ronald H Schwartz*
Correspondence *Laboratory of Cellular and Molecular Immunology, Building 4, Rm 111, MSC-0420, NIAID-NIH, Bethesda, MD 20892-0420, USA
Email rs34r@niaid.nih.gov
Autoimmune responses are an inherent consequence of the wide repertoires of T-cell and B-cell receptors, which are needed in order for these cells to recognize a broad range of pathogens. This review explains the strategies used by the immune system to prevent and regulate the generation of autoreactive receptors and maintain immunologic tolerance.
Full text of this article is available with one of the following:
- Personal subscription Purchase your own personal subscription to this journal. Already a subscriber? Please log in for immediate access.
- 7 day single article pass for US$32 In order to purchase this article you must be a registered user. Please register or log in.
- Site licence Learn more about institutional site licences
Current Subscribers
Please log in to access the full text article using the login box at the top of the page.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Policing the regulatorsNature Immunology News and Views (01 Apr 2001)
Autoimmunity heats upNature Medicine News and Views (01 Dec 2003)
See all 4 matches for News And ViewsRESEARCH
BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responsesThe EMBO Journal Article (11 Jul 2007)
See all 30 matches for Research