SATB1 expression generates gene-expression profiles that promote breast tumor metastasis

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Gene-expression analyses of human breast cancer cell lines that are associated with a poor outcome have revealed characteristic expression patterns that can predict metastasis (or metastatic risk), but how such gene-expression profiles confer metastatic potential is unclear. Han et al. have described a genome organizer protein—SATB1—that when expressed in breast cancer cells can establish a pattern of gene expression that is consistent with invasive behavior.

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