Mechanisms of Disease: the role of stem cells in the biology and treatment of gliomas
Jörg Dietrich*, Jaime Imitola and Santosh Kesari*
Correspondence *Department of Neurology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
Email jdietrich1@partners.org
Correspondence *Center for Neuro-Oncology, Dana-Farber Cancer Institute, SW430, 44 Binney Street, Boston, MA 02115, USA
Email skesari@partners.org
Brain tumors may harbor small subpopulations of cells that share characteristics of neural stem cells. The use of neural stem cells and progenitor cells as delivery vehicles of molecules toxic to tumors offers a promising experimental treatment strategy. This Review summarizes recent advances in the basic understanding of neural stem cell and cancer-stem-cell biology and the progress towards translating these novel concepts into the clinic.
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