Regional lymphadenectomy should be standard for metastasis from melanoma of unknown primary
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Studies examining the prognostic significance of melanoma of unknown primary (MUP) have produced inconsistent results and it is unclear whether patients with MUP require more-aggressive management than patients with known primary melanoma (MKP). Now, Lee et al. have commented that they have conducted the largest ever review of the outcomes of patients with MUP and palpable regional metastasis in a single lymphatic basin, to determine survival rates and prognostic factors.
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