Chemokines mediate preferential metastasis of cutaneous melanoma to the small intestine
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Evidence is accumulating to indicate that chemokines might have a role in tumor-cell trafficking. Recent studies have shown that CCL25—which mediates the chemotaxis of CCR9+ cells—is an important chemokine involved in cellular homing to the small intestine. On the basis of these data, Amersi et al. hypothesized that chemokine-mediated homing via the CCR9–CCL25 axis might be the primary mechanism by which cutaneous melanomas preferentially metastasize to the small intestine.
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