Review

Nature Clinical Practice Oncology (2008) 5, 280-290
doi:10.1038/ncponc1089  
Received 4 April 2007 | Accepted 26 October 2007 | Published online: 18 March 2008

Mechanisms of Disease: epithelial–mesenchymal transition—does cellular plasticity fuel neoplastic progression?

Eva A Turley, Mandana Veiseh, Derek C Radisky and Mina J Bissell*

Correspondence *Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977, Berkeley, CA 94720, USA

Email mjbissell@lbl.gov

Epithelial–mesenchymal transition (EMT) is a phenotypic conversion that facilitates organ morphogenesis and tissue remodeling. The authors of this Review discuss the phenomenon of EMT in relation to tumor development, and the function of EMT in promoting invasion and metastasis. The roles of ERK1, ERK2 and PI3-kinase, as microenvironmental responsive regulators of EMT are also highlighted.

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