Review

Nature Clinical Practice Oncology (2007) 4, 344-352
doi:10.1038/ncponc0839  
Received 18 October 2006 | Accepted 6 March 2007

Malignant pleural mesothelioma: current concepts in treatment

Athanasios Tsiouris* and Robin K Walesby

Correspondence *Basement flat 2, 359 Camden Road, London N7 0SH, UK

Email
 athtsiouris@hotmail.com

Malignant pleural mesothelioma (MPM) is a common primary tumor of the pleura. Current therapeutic regimens that involve surgery, chemotherapy and radiotherapy have offered marginal clinical benefits. Histological subtype, lymph-node involvement, resection margins and invasion beyond the pleura are significant factors that dictate survival. This review discusses the multimodality approach, which is considered the cornerstone of treatment of MPM, although the authors emphasize that the exact combination of treatment options for this disease have yet to be defined.

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