Mechanisms of Disease: genetic predictors of response to treatment in brain tumors
V Peter Collins
Correspondence Department of Histopathology, University of Cambridge, Addenbrooke's Hospital, Box 235, Hills Road, Cambridge CB2 2QQ, UK
Email vpc20@cam.ac.uk
Brain tumors are currently diagnosed on the basis of their histology, but recent findings indicate that in some cases response to conventional therapy correlates with genetic characteristics rather than histopathology. An understanding of the molecular mechanisms that underlie the malignant phenotype of gliomas also provides the possibility of rational design of molecular targeted therapies, as discussed in this review.
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