Immunological markers can predict risk of transformation of FL to aggressive DLBCL
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Despite the existence of different treatment options, follicular lymphoma (FL) is considered incurable. In patients with FL, transformation to aggressive diffuse large B-cell lymphoma (DLBCL) is the major cause of disease-related death. It has been suggested that the outcome in patients with FL is determined by the interaction of tumor cells with immune cells in the surrounding microenvironment. A study by Glas et al. has confirmed this hypothesis and shown that expression of immunological markers can predict risk of transformation in patients with FL.
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