Postoperative radiochemotherapy improves outcome in head and neck cancer
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Locoregional failure occurs in a considerable proportion of patients with squamous-cell head and neck carcinoma, despite aggressive surgical treatment and postoperative irradiation. Several studies have indicated an improved outcome in patients treated with postoperative concomitant radiochemotherapy with cisplatin. Zakotnik et al. carried out a randomized trial to compare the long-term results of treatment with concomitant postoperative radiochemotherapy with mitomycin C and bleomycin (CRT), with those of postoperative radiotherapy only (RT).
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