Basal subtype breast carcinomas express EGFR and might be candidates for targeted therapy
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The recent discovery that the different types of breast carcinoma have distinctive gene expression signatures has enabled tumor subtypes to be easily identified by immunohistochemical profiling techniques. Breast carcinoma subtypes are associated with different clinical outcomes, and targeted therapies might be appropriate in some cases. Here, Siziopikou and Cobleigh suggest that the basal subtype of breast carcinomas might be a candidate for therapies targeted against EGFR.
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