Viewpoint

Nature Clinical Practice Oncology (2007) 4, 204-205
doi:10.1038/ncponc0771  
Received 26 September 2006 | Accepted 12 December 2006

Hormone receptors in defining breast cancer prognosis—time for a rethink?

Valerie Speirs* and Abeer M Shaaban

Correspondence *Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St James's University Hospital, Beckett Street, Leeds LS9 7TK, UK

Email
 v.speirs@leeds.ac.uk

ERalpha and ERbeta are structurally and functionally distinct, but currently only ERalpha is used to guide clinicians. The authors of this Viewpoint discuss whether this strategy is sufficiently informative, and how outcome and tumor response to adjuvant hormonal therapy can be followed more effectively.

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