Duplicated TMPRSS2–ERG fusion predicts extremely poor outcome in prostate cancer
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The recently reported association between fusion of the TMPRSS2 and ERG genes and prostate cancer has raised the possibility that alterations at the ERG locus could provide prognostic information independent of that provided by Gleason score. Now, Attard et al. have assessed the prognostic utility of ERG locus alterations in a cohort of 445 conservatively managed patients with prostate cancer.
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