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Nature Clinical Practice Oncology (2007) 4, 617-618
doi:10.1038/ncponc0924  

Poor results with intensified maintenance chemotherapy in acute promyelocytic leukemia

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A prospective, multicenter study by the Japan Adult Leukemia Study Group, JALSG APL97, has shown that moderately intensive intermittent maintenance chemotherapy is detrimental to the survival of patients with acute promyelocytic leukemia (APL) who have become negative for the PML-RARalpha transcript after intensive consolidation chemotherapy.

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