Review

Nature Clinical Practice Oncology (2006) 3, 428-437
doi:10.1038/ncponc0564  
Received 18 January 2006 | Accepted 28 April 2006

Male breast cancer: a gender issue

Zeina Nahleh and Saulius Girnius

Correspondence Division of Hematology-Oncology, University of Cincinnati, The Barrett Cancer Center, ML-0501, 234 Goodman Street, Cincinnati, OH 45267, USA

Email
 nahlehza@ucmail.uc.edu

The incidence of male breast cancer is rising, and the treatment of this disease has been extrapolated from the knowledge of female breast cancer despite multiple differences in the pathogenesis, biology and genetics of these two disease entities. Although there have been major advances in hormonal manipulation for the treatment of breast cancer, an improved understanding of the potential differences between male and female breast cancer is essential to providing new opportunities for therapeutic intervention and likely improved outcome, as discussed in this review.

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