Insulin and risk of pancreatic cancer
Jim Casey
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Type 2 diabetes has been associated with pancreatic cancer, but it is unclear whether diabetes is a causative factor or the result of subclinical malignancy. Insulin has been shown to have mitogenic effects on pancreatic cancer cells, and hyperinsulinemia is known to occur in the early stages of type 2 diabetes, suggesting a mechanism by which insulin might have a carcinogenic effect in the pancreas. Stolzenberg-Solomon et al. sought to determine whether prediagnostic glucose and insulin levels and insulin resistance were linked to subsequent incidence of pancreatic cancer in a cohort of Finnish male smokers participating in the ATBC STUDY. Only cancer cases that occurred after the fifth year of follow-up were included in the study.
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